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Estrogen. Progesterone. Testosterone. They regulate over 400 functions in your body. During perimenopause, all three shift. But here's what nobody tells you: the research on what to do about it has changed dramatically in the last two years. You have more options than you think. Let's walk through them.
Every claim sourced. Tap any source to verify it yourself.
See Your OptionsEstrogen drops by up to 90% by menopause. That's not a subtle shift. That's a system overhaul.
Your testosterone is already half of its peak by age 40. Most women have no idea they even produce it.
of women get hot flashes during menopause. The average is 4 to 5 per day. For up to 7 years.
of your skin collagen disappears in the first five years after menopause.
Real data on hormones and perimenopause barely exists. Help us change that.
Hormone Levels by Age
Progesterone (first to decline, starts around 35)
Estrogen (spikes then crashes, drops up to 90%)
Testosterone (gradual decline, half by age 40)
Sources: Jean Hailes for Women's Health; Davis et al., 2000; Cleveland Clinic; London Hormone Clinic, 2025
For the first time in over 20 years, the FDA removed cardiovascular disease and breast cancer warnings from select menopausal hormone therapy products. This is the biggest regulatory shift in menopause care since the WHI study scared an entire generation off HRT in 2002.
Prometrium
Micronized progesterone
Bijuva
Estradiol + progesterone
Divigel
Estradiol gel
Cenestin
Synthetic conjugated estrogens
Enjuvia
Synthetic conjugated estrogens
Estring
Estradiol vaginal ring
We rejected 4 popular products. Here's why.
Every product we recommend has to pass our evidence standard. These didn't.
The supplement that shows up most consistently across hormonal health research. Not a replacement for HRT. A starting point.
Magnesium is involved in over 300 enzymatic reactions including hormone production. Schuster et al. 2025 published in Nature and Science of Sleep ran an RCT with 155 adults and found magnesium bisglycinate significantly improved sleep quality versus placebo. NSF GMP Registered facility. Most women are deficient, and it is the one supplement that shows up across sleep, mood, and hormonal health research.
Every product is selected based on published clinical data, not sponsorship. See the full evidence on our What Works page.
Your hormones are changing. That's a fact. But the science has changed too. The options are better than they've ever been. Get your levels tested. Find a doctor who actually understands perimenopause. Talk to them about what's right for your body.
This page gives you the data. Your doctor gives you the plan.
Last reviewed: March 2026
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